Evaluation of the Anti-Obesity Activity of Evolvulus nummularius and Jatropha integerrima Leaf Extracts in HFD-Induced Obese Mice
Abstract
The study conducted in this particular research involved the use of a model involving obesity caused by a High Fat Diet (HFD) in female mice of the species Swiss albino to investigate the possible anti-obesity effects of ethanolic leaves extract from two plants, namely Evolvulus nummularius and Jatropha integerrima. The HFD diet was administered via oral route in doses of 10 mg/kg body weight for 28 consecutive days to induce experimental obesity. In this particular research, the standard reference was orlistat at a 10 mg/kg dose, whereas the plant extract doses were at 200 mg/kg and 400 mg/kg body weight. The following variables were recorded on a weekly basis throughout the duration of this experiment: body weight gain, BMI, and food consumption. Moreover, other serum biochemical markers such as total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were determined at the end of the treatment duration. Compared to the HFD-treated control group, there was a statistically significant reduction in body weight gain, BMI, and fat deposition with increased HDL-C as well as reduced TC, TG, and LDL-C, among other benefits associated with the administration of both plant extracts, especially at a dose of 400 mg/kg. Furthermore, histological examination confirmed the presence of reduced adipocyte hypertrophy among the treated mice. Bioactive phytochemicals such as flavonoids, saponins, and phenolics, which affect lipid metabolism and inhibit adipogenesis, could be the cause of the benefits obtained. All of these results point to the chosen plant extracts' potential as natural therapeutic agents for the treatment of hormone-induced obesity.
How to Cite
Sarika Chaturvedi, Sushila Kaura, "Evaluation of the Anti-Obesity Activity of Evolvulus nummularius and Jatropha integerrima Leaf Extracts in HFD-Induced Obese Mice", Vol. 4, Issue 1, 24-04-2026, pp. 41-54.
