PREPARATION OF URSOLIC ACID LOADED GUM GHATTI NANOCARRIER

AUTHOR

Rajat Lathwal

Department of Biotechnology, JVWU, Jaipur

ABSTRACT  

Ursolic acid (UA), a naturally occurring pentacyclic triterpenoid compound, possesses promising therapeutic activities, particularly in combating cancer. However, its clinical application is significantly hindered due to poor aqueous solubility and low bioavailability. The present research focuses on developing a novel nanocarrier system using gum ghatti, a natural hydrophilic polymer, for encapsulating UA via nanoprecipitation. The resulting ursolic acidloaded gum ghatti nanoparticles (UGNPs) were characterized for size, morphology, encapsulation efficiency, and drug release behavior. UGNPs demonstrated a narrow size distribution ranging from 22 to 39 nm and an encapsulation efficiency of 60%. The controlled and sustained drug release over 24 hours, along with stable morphology, signifies the potential of gum ghatti as an effective and eco-friendly nanocarrier system.

Keywords: Ursolic acid, Gum ghatti, Nanoparticles, Sustained release, Natural polymer, Bioavailability enhancement